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Vacuum emulsifying machineThe vacuum homogenizing emulsifier equipment is non-standard customized equipment, which is reasonably configured according to the customer's process, and is suitable for products that need to be emulsified and stirred in a vacuum state.
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The company has established the enterprise goal of "survival by quality, reputation by quality, and development by quality. Strengthen the training of technical personnel, and constantly enrich the first-line technical force to ensure the normal operation of the quality assurance system.
Application of Vacuum Emulsifier in Medical Field
Release time:
2022-06-17
As the name implies, the vacuum emulsifying machine refers to the material in the vacuum state, the use of vacuum emulsifying machine efficiently, quickly and evenly distributed in different phases, usually the oil phase and water are equal to each other incompatible. Using the strong kinetic energy brought by the machine, the material can withstand hundreds of thousands of times per minute of fluid shearing, centrifugal extrusion, collision fracture and parallel flow in a constant and narrow rotor gap, so that the incompatible phase can be evenly dispersed and emulsified instantly under the combined action of the corresponding mature process and appropriate amount of additives, and can circulate at high frequency. Then, let's understand the purpose and scope of application of the vacuum emulsifying machine.
The entire production process of ointments, creams and other emulsion drugs-strictly in accordance with product hygiene or sterile level standards management, a variety of raw materials under controlled, safe, repeatable conditions,vacuum emulsifying machineUsing quantitative methods for homogenization, heating, cooling, sterilization and filling, the production system includes on-line cleaning, on-line sterilization, on-line drying and other devices, and also automates the entire production process to meet the requirements of good automated manufacturing standards, so let's learn about the application of vacuum emulsifying machine in the field of medicine!
Material circulation of vacuum emulsifying machine
After the two-phase mixing, the product returns to the container through the rotor/stator push cycle, enters the container through the homogenizer from under the container, and returns to the homogenizer. This forced circulation path allows the company to accurately evaluate the time required for the entire batch. By recording the time for the raw material to pass through the rotor stator homogenizer once, the required number of cycles and homogenization time can be calculated. Another advantage of the material circulation is evident in the heating and cooling process, especially in the case of a large number of large containers, it is difficult to maintain a uniform temperature only by the product itself, but by using the material external circulation, the radial temperature distribution can be made relatively constant. In addition, by applying a high level of vacuum at the end of the process, air bubbles can be reliably removed and a smooth, glossy and stable product can be produced.
vacuum emulsifying machinedefoaming process
Depending on the nature of the product, its density may be significantly reduced at the process stage. The defoaming process has a significant impact on downstream filling accuracy, productivity-product and container type, and determines the tolerance requirements for volumetric filling. If appropriate defoaming can be performed before filling, the filling accuracy can be easily kept within a tolerance range. In the emulsion tank, after the product has been defoamed, it can be discharged from the buffer container by the pumping action of the homogenizer. At this time, the variable stator plays an important role. In the homogeneous mode, the rotor is close to the stator, which has a very strong shearing effect on the product; on the other hand, in the pump mode, by adjusting the position of the stator, the rotor and the stator can be separated, and the shearing effect is greatly reduced. Therefore, in the pump mode, the temperature rise of the material discharged from the homogenizer is very small.
Vacuum emulsifying machine to expand the process
Usually the formula and process are developed on a laboratory scale, with a batch of about 1 to 10kg, and transferred to large-scale production equipment with a batch of more than 1000 kg after the development is completed. When developing unknown formulations and technologies, it is clear that the production of the technology and products will become larger and more unpredictable, which brings great risks. To completely avoid such events throughout the product life cycle, develop an accurate and complete scale-up model based on the parameters. Looking closely at each step in the process, you will find that if the batch is multiplied by 10, not all sizes and elements grow at the same rate. How the system works
In the vacuum homogenizer system, the homogenizer of the fixed rotor structure is below the main tank body. The position of the status slider can be adjusted to facilitate the removal of the stator from the high shear area. The product of the main tank body is delivered to the homogenizer through the outlet at the bottom of the tank, which is also the inlet of the homogenizer. Next, in the premixing chamber, the mixing delivery paddles accelerate the product downward. There are multiple feed valves around the pre-mixing chamber, through which powder and liquid are sucked in under vacuum.
vacuum emulsifying machineAseptic operation
For pharmaceutical products, there are strict standards from laboratory samples to commercial production. This is to ensure the purity and quality of the product. The vacuum homogenizing emulsifier can be designed according to the process requirements to meet different production needs. This configuration of the isolator can not only provide sufficient product protection for sterile feeding, but also protect the operator, which is very important when adding high-activity ingredients.
The above is the application of vacuum emulsifying machine in the field of medicine, if you need to know more, you can contact us at any time!
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