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Study on pilot scale-up of homogeneous emulsifying machine


Release time:

2019-07-11

Research on pilot scale-up of homogeneous emulsifying machine 1) Review of production process route In general, the method of unit reaction and production process route should be basically selected at the laboratory stage. In the pilot scale-up stage, only specific process operations and conditions are determined to suit industrial production. However, when the selected process route and process, in the pilot scale-up exposed a major problem that is difficult to overcome, it is necessary to review the laboratory process route, modify its process. 2) Homogeneous emulsifying machine equipment material and type of selection of the beginning of the pilot scale-up should consider the material and type of various equipment required, and check whether it is appropriate, especially should pay attention to contact corrosion

Study on pilot scale-up of homogeneous emulsifying machine
1) Review of production process route
In general, the method and production process route of the unit reaction should be basically selected at the laboratory stage. In the pilot scale-up stage, only specific process operations and conditions are determined to suit industrial production. However, when the selected process route and process, in the pilot scale-up exposed a major problem that is difficult to overcome, it is necessary to review the laboratory process route, modify its process.
2)Homogenizing emulsifying machineSelection of Equipment Material and Type
At the beginning of the pilot scale-up, the materials and types of the required equipment should be considered, and the suitability should be examined, with particular attention to the selection of materials for equipment that contacts corrosive materials.
3) Examination of stirrer type and stirring speed
Most of the reactions in drug synthesis are heterogeneous reactions, and the thermal effect of the reaction is large.
In the laboratory, due to the small volume of materials and good stirring efficiency, the problems of heat and mass transfer are not obvious, but in the pilot scale-up, due to the influence of stirring efficiency, the problems of heat and mass transfer are prominently exposed. Therefore, the pilot scale-up must pay attention to the study of the type of stirrer according to the nature of the material and the characteristics of the reaction, and examine the effect of stirring speed on the reaction law, especially in solid.-When the liquid is non-homogeneous reaction, the stirrer type and suitable stirring speed shall be selected according to the reaction requirements.
4)Homogenizing emulsifying machineFurther study of reaction conditions
obtained in the laboratory phaseZui good reaction conditions may not meet the requirements of pilot scale-up. The main influencing factors, such as the feeding rate in the exothermic reaction, the heat transfer area and heat transfer coefficient of the reaction tank, and the refrigerant, should be studied in depth, and their changes in the pilot plant should be mastered to obtain more suitable reaction conditions.
5) Determination of process flow and operation method of homogeneous emulsifying machine
In the pilot scale-up stage, due to the increase of processing materials, it is necessary to consider how to adapt the operation method of reaction and post-treatment to the requirements of industrial production, with special attention to shorten the process and simplify the operation.
6) Quality control of raw and auxiliary materials and intermediates
① Determination of physical properties and chemical parameters of raw and auxiliary materials and intermediates.
② Development of quality standards for raw and auxiliary materials and intermediates.